El impacto de la tenacidad en el rendimiento académico en la educación superior

El rendimiento académico ocupa un lugar sumamente importante a nivel internacional debido a las elevadas tasas de abandono y fracaso escolar. En este sentido, la tenacidad se encuentra estrechamente relacionada con el rendimiento académico, es por lo que el objetivo de este estudio fue explorar la relación entre la tenacidad y el rendimiento académico en 576 estudiantes de la Universidad de Granada. Para ello, se realizó la prueba H de Kruskal-Wallis para muestras independientes y la prueba U de Mann Whitney para dos muestras independientes para identificar la presencia de diferencias en tenacidad en función de edad, sexo, titulación y curso, y rendimiento académico en función de la tenacidad y el análisis de correlación de Spearman entre las variables del estudio. Los resultados revelaron diferencias estadísticamente significativas en perseverancia en el esfuerzo en función de la titulación, así como en perseverancia en el esfuerzo y tenacidad en función del sexo. Asimismo, se encontraron diferencias estadísticamente significativas en el rendimiento académico de los participantes en función de su nivel de tenacidad, con una tendencia a presentar un mayor rendimiento académico el alumnado universitario con mayor nivel de tenacidad. Estos resultados suponen un avance en lo que respecta a los estudios relacionados con la tenacidad en el contexto español, pues parece que esta habilidad no cognitiva tiene incidencia en el rendimiento académico del alumnado de universitario, con las implicaciones que ello conlleva

The Expanding Phenotypical Spectrum of WARS2 -Related Disorder : Four Novel Cases with a Common Recurrent Variant

Biallelic variants in the mitochondrial form of the tryptophanyl-tRNA synthetases (WARS2) can cause a neurodevelopmental disorder with movement disorders including early-onset tremor-parkinsonism syndrome. Here, we describe four new patients, who all presented at a young age with a tremor-parkinsonism syndrome and responded well to levodopa. All patients carry the same recurrent, hypomorphic missense variant (NM_015836.4: c.37T>G; p.Trp13Gly) either together with a previously described truncating variant (NM_015836.4: c.797Cdel; p.Pro266ArgfsTer10), a novel truncating variant (NM_015836.4: c.346C>T; p.Gln116Ter), a novel canonical splice site variant (NM_015836.4: c.349-1G>A), or a novel missense variant (NM_015836.4: c.475A>C, p.Thr159Pro). We investigated the mitochondrial function in patients and found increased levels of mitochondrially encoded cytochrome C Oxidase II as part of the mitochondrial respiratory chain as well as decreased mitochondrial integrity and branching. Finally, we conducted a literature review and here summarize the broad phenotypical spectrum of reported WARS2 -related disorders. In conclusion, WARS2 -related disorders are diagnostically challenging diseases due to the broad phenotypic spectrum and the disease relevance of a relatively common missense change that is often filtered out in a diagnostic setting since it occurs in ~0.5% of the general European population

Poesía y cuidados: una herramienta para las emociones

El objetivo de este trabajo es desarrollar una herramienta de reflexión y sentimientos que contribuyan a la gestión emocional de los alumnos de enfermería en sus prácticas clínicas. Se ha empleado un grupo de poemas derivados de experiencias clínicas como base para la identificación y análisis de emociones y sentimientos. Se utilizó la taxonomía de Heller (1989) para facilitar su análisis. Los principales resultados afirman el gran reto que tenemos los docentes en dotar a los futuros enfermeros de la capacidad cognitiva y las destrezas emocionales necesarias para gestionar el aluvión de sentimientos complejos e intensos que emergen durante la aplicación del proceso de enfermería con el fin de prepararlos para el trabajo emocional inherente a su trabajo y disminuir el riesgo de “burnout”. Con lo que podemos concluir que los poemas inspirados en experiencias clínicas constituyen una herramienta pertinente para facilitar el trabajo emocional y de sentimientos generados durante las prácticas clínicas

Antropología emocional y estética de los cuidados en las prácticas clínicas de enfermería

Reflexionar sobre los sentimientos inspirados a los alumnos por la lectura de poemas centrados en vivencias de la práctica clínica desde la perspectiva de la sociopoética. Metodológicamente se utilizaron poemas derivados de experiencias clínicas para la reflexión intersubjetiva de los sentimientos. Se utilizaron las orientaciones de Santos (2005) y Santos & Gauthier (1999) para la reflexión sociopoética/ intersubjetiva de los sentimientos. La teoría reflexiva y el concepto de “habitus” de Bordieu (1995) se emplearon para potenciar concienciación del proceso de construcción social de los sentimientos. Para la categorización se siguió la teoría de los sentimientos (Heller, 2004). Desarrollo del tema: La confrontación entre el “habitus” (mundo personal) de los alumnos y la cultura institucional imperante en la clínica donde se desarrollan las prácticas (espacio social), provoca la necesidad de readaptación del alumno. La concienciación de los sentimientos constituye un recurso para disminuir el estrés. Los sentimientos identificados se distribuyen en cuatro categorías: desagradables, morales, altruistas y estéticos. Conclusiones: La sociopoética permite la reflexión colectiva sobre los sentimientos facilitando el análisis intersubjetivo de los mismos y contribuye a la gestión emocional y al desarrollo del humanismo

Acute and long-term immune responses to SARS-CoV-2 infection in unvaccinated children and young adults with inborn errors of immunity

PurposeTo describe SARS-CoV-2 infection outcome in unvaccinated children and young adults with inborn errors of immunity (IEI) and to compare their specific acute and long-term immune responses with a sex-, age-, and severity-matched healthy population (HC).MethodsUnvaccinated IEI patients up to 22 years old infected with SARS-CoV-2 were recruited along with a cohort of HC. SARS-CoV-2 serology and ELISpot were performed in the acute phase of infection (up to 6 weeks) and at 3, 6, 9, and 12 months.ResultsTwenty-five IEI patients (median age 14.3 years, min.-max. range 4.5-22.8; 15/25 males; syndromic combined immunodeficiencies: 48.0%, antibody deficiencies: 16.0%) and 17 HC (median age 15.3 years, min.-max. range 5.4-20.0; 6/17 males, 35.3%) were included. Pneumonia occurred in 4/25 IEI patients. In the acute phase SARS-CoV-2 specific immunoglobulins were positive in all HC but in only half of IEI in whom it could be measured (n=17/25): IgG+ 58.8% (10/17) (p=0.009); IgM+ 41.2% (7/17)(p<0.001); IgA+ 52.9% (9/17)(p=0.003). Quantitative response (index) was also lower compared with HC: IgG IEI (3.1 ± 4.4) vs. HC (3.5 ± 1.5)(p=0.06); IgM IEI (1.9 ± 2.4) vs. HC (3.9 ± 2.4)(p=0.007); IgA IEI (3.3 ± 4.7) vs. HC (4.6 ± 2.5)(p=0.04). ELISpots positivity was qualitatively lower in IEI vs. HC (S-ELISpot IEI: 3/11, 27.3% vs. HC: 10/11, 90.9%; p=0.008; N-ELISpot IEI: 3/9, 33.3% vs. HC: 11/11, 100%; p=0.002) and also quantitatively lower (S-ELISpot IEI: mean index 3.2 ± 5.0 vs. HC 21.2 ± 17.0; p=0.001; N-ELISpot IEI: mean index 9.3 ± 16.6 vs. HC: 39.1 ± 23.7; p=0.004). As for long term response, SARS-CoV-2-IgM+ at 6 months was qualitatively lower in IEI(3/8, 37.5% vs. 9/10 HC: 90.0%; p=0.043), and quantitatively lower in all serologies IgG, M, and A (IEI n=9, 1.1 ± 0.9 vs. HC n=10, 2.1 ± 0.9, p=0.03; IEI n=9, 1.3 ± 1.5 vs. HC n=10, 2.9 ± 2.8, p=0.02; and IEI n=9, 0.6 ± 0.5 vs. HC n=10, 1.7 ± 0.8, p=0.002 –respectively) but there were no differences at remaining time points.ConclusionsOur IEI pediatric cohort had a higher COVID-19 pneumonia rate than the general age-range population, with lower humoral and cellular responses in the acute phase (even lower compared to the reported IEI serological response after SARS-CoV-2 vaccination), and weaker humoral responses at 6 months after infection compared with HC

Extracellular vesicles from pristane-treated CD38-deficient mice express an antiinflammatory neutrophil protein signature, which reflects the mild lupus severity elicited in these mice

In CD38-deficient (Cd38-/-) mice intraperitoneal injection of pristane induces a lupus-like disease, which is milder than that induced in WT mice, showing significant differences in the inflammatory and autoimmune processes triggered by pristane. Extracellular vesicles (EV) are present in all body fluids. Shed by cells, their molecular make-up reflects that of their cell of origin and/or tissue pathological situation. The aim of this study was to analyze the protein composition, protein abundance, and functional clustering of EV released by peritoneal exudate cells (PECs) in the pristane experimental lupus model, to identify predictive or diagnostic biomarkers that might discriminate the autoimmune process in lupus from inflammatory reactions and/or normal physiological processes. In this study, thanks to an extensive proteomic analysis and powerful bioinformatics software, distinct EV subtypes were identified in the peritoneal exudates of pristane-treated mice: 1) small EV enriched in the tetraspanin CD63 and CD9, which are likely of exosomal origin; 2) small EV enriched in CD47 and CD9, which are also enriched in plasma-membrane, membrane-associated proteins, with an ectosomal origin; 3) small EV enriched in keratins, ECM proteins, complement/coagulation proteins, fibrin clot formation proteins, and endopetidase inhibitor proteins. This enrichment may have an inflammation-mediated mesothelial-tomesenchymal transition origin, representing a protein corona on the surface of peritoneal exudate EV; 4) HDL-enriched lipoprotein particles. Quantitative proteomic analysis allowed us to identify an anti-inflammatory, Annexin A1- enriched pro-resolving, neutrophil protein signature, which was more prominent in EV from pristane-treated Cd38-/- mice, and quantitative differences in the protein cargo of the ECM-enriched EV from Cd38-/- vs WT mice. These differences are likely to be related with the distinct inflammatory outcome shown by Cd38-/- vs WT mice in response to pristane treatment. Our results demonstrate the power of a hypothesis-free and data-driven approach to transform the heterogeneity of the peritoneal exudate EV from pristanetreated mice in valuable information about the relative proportion of different EV in a given sample and to identify potential protein markers specific for the different small EV subtypes, in particular those proteins defining EV involved in the resolution phase of chronic inflammation.Proyecto del plan estatal, Ministerio de Ciencia e Innovacion PT13/0001/011CSIC PT17/0019/0010 PID2020-119567RB-I0

Modelo de gestión clínica para las enfermedades nefrológicas en Aragón. Utilidad de un programa de calidad asistencial

Introducción y objetivos: A través de un grupo de trabajo interdisciplinario se elabora un “Documento Marco sobre el Abordaje de la Enfermedad Renal Crónica en Aragón” en el que se detectan oportunidades de mejora, se determinan objetivos, se fijan planes, programas y acciones a realizar y se considera un horizonte temporal. Pretendemos analizar los principales indicadores de evolución del proceso. Material y método: Se revisa la evolución a 5 años de los principales indicadores de procesos estructurales, organizativos y clínicos. Resultados: Evolución procesos estructurales: Hemodiálisis con agua ultrapura: pasa de 64% a 100%; monitores hemodiálisis con antigüedad mayor de 10 años: 36 % a 2 %. Procesos organizativos: técnicas especiales de hemodiálisis: 12 % a 22 %; inicio programado en ERCA: 70 % a 88 %; ERCA como origen de diálisis: 0 % a 57,4 %; inicio con acceso vascular definitivo: 40 % a 48 %; manejo conservador: no programado al inicio a 20 %; trasplante renal de donante vivo: 5,3 a porcentajes superiores al 15 %; Diálisis Peritoneal: 8,9 a 28,2 %. Procesos clínicos: KTV a 6 meses superior a 1,3: 52 a 78 %; episodios peritonitis: 1/31,2 a 1/43,6 meses. Conclusiones: La Planificación Sanitaria supone un mestizaje entre gestión y conocimiento médico orientado al máximo beneficio del paciente. Una adecuada gestión clínica trae consigo procesos estandarizados con disminución de la variabilidad y garantía de idoneidad de cuidados. Esta política organizativa ha permitido la mejoría de los indicadores de calidad seleccionados, con una mayor eficiencia del proceso sanitario

Is systematic training in opioid overdose prevention effective?

The objectives were to analyze the knowledge about overdose prevention, the use of naloxone, and the number of fatal overdoses after the implementation of Systematic Training in Overdose Prevention (STOOP) program. We conducted a quasi-experimental study, and held face-to-face interviews before (n = 725) and after (n = 722) implementation of systematic training in two different samples of people who injected opioids attending harm reduction centers. We asked participants to list the main causes of overdose and the main actions that should be taken when witnessing an overdose. We created two dependent variables, the number of (a) correct and (b) incorrect answers. The main independent variable was Study Group: Intervention Group (IG), Comparison Group (CG), Pre-Intervention Group With Sporadic Training in Overdose Prevention (PREIGS), or Pre-Intervention Group Without Training in Overdose Prevention (PREIGW). The relationship between the dependent and independent variables was assessed using a multivariate Poisson regression analysis. Finally, we conducted an interrupted time series analysis of monthly fatal overdoses before and after the implementation of systematic program during the period 2006-2015. Knowledge of overdose prevention increased after implementing systematic training program. Compared to the PREIGW, the IG gave more correct answers (IRR = 1.40;95%CI:1.33-1.47), and fewer incorrect answers (IRR = 0.33;95%CI:0.25-0.44). Forty percent of people who injected opioids who received a naloxone kit had used the kit in response to an overdose they witnessed. These courses increase knowledge of overdose prevention in people who use opioids, give them the necessary skills to use naloxone, and slightly diminish the number of fatal opioid overdoses in the city of Barcelon

Determinación de procesos de fractura sobre huesos frescos: un sistema de análisis de los ángulos de los planos de fracturación como discriminador de agentes bióticos

The breakage planes of bones have diversely been used to classify breakage patterns. However, no diagnosis seems to be currently valid to differentiate between humans and carnivores as the main breaking agents. This work presents the results of experimentation focused on the analysis of the angles of each plane between the cortical and medullary surfaces resulting from breakage. It is shown that this approach can be fairly resolutive since both types of agents break bones through different physical processes (percussion and pression) which produce different angles in each fracture episode, as a result of the use of dynamic and static loading processes.Los paños de fractura de los huesos siempre se han prestado a diversos análisis de clasificación, pero con menor éxito se ha podido averiguar el (los) agente(s) responsable( s) de su ruptura. De los diversos atributos utilizados, uno de ellos (los ángulos de los planos de fractura) se ha sometido a exhaustivo análisis, con los resultados que se ofrecen en el presente trabajo. Se concluye que dichos ángulos, en su consideración global en una muestra pueden ser resolutivos ya que los diversos agentes bióticos que rompen huesos (humanos y carnívoros) lo hacen por procesos físicos distintos (percusión y presión) que provocan diagnosis diferenciadas en el modo en que los huesos aparecen fracturados

Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study

Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis